Important Safety Information and Warnings
Pediatrics: Vardenafil trials were not conducted in the pediatric population.
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It remains safe for most with mild impairment under medical supervision. Efficacy of patients with LEVITRA treatmentdate_rangeTime Frame:After 6 monthsenhanced_encryptionNoSafety Issue: LEVITRA treatment improved the patient's erectiondate_rangeTime Frame:After 6 monthsenhanced_encryptionNoSafety Issue: LEVITRA improved the patient's erection after Minimum and Maximum Intervals between LEVITRA intake and the start of intercoursedate_rangeTime Frame:After 6 monthsenhanced_encryptionNoSafety Issue: Reporting a second successful intercourse within 24 hours of dosingdate_rangeTime Frame:After 6 monthsenhanced_encryptionNoSafety Issue: Patients prefer LEVITRA over last Erectile Dysfunction treatmentdate_rangeTime Frame:After 6 monthsenhanced_encryptionNoSafety Issue: Tolerability of patients with LEVITRA treatmentdate_rangeTime Frame:After 6 monthsenhanced_encryptionYesSafety Issue: Generic name: vardenafil Other brand names of vardenafil include: Levitra Drug class: Impotence medications The Levitra brand name has been discontinued in the U.S. If generic generic levitra without rx versions of this product have been approved by the FDA, there may be generic equivalents available. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. LEVITRA- vardenafil hydrochloride tablet, film coated APHENA PHARMA SOLUTIONS - TENNESSEE, INC.
Is 20mg of Levitra strong?
LEVITRA® is an oral therapy for the treatment of erectile dysfunction. Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water. LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10”, and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. Penile erection is a hemodynamic process initiated by the relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum.
What is Levitra 20 mg used for?
Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMP-specific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation. Geriatrics: In a healthy volunteer study of elderly males (≥65 years) and younger males (18–45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males (see PRECAUTIONS, Geriatric Use and DOSAGE AND ADMINISTRATION). Consequently, a lower starting dose of LEVITRA (5 mg) in patients ≥65 years of age should be considered. Renal Insufficiency: In volunteers with mild renal impairment (CLcr = 50-80 ml/min), the pharmacokinetics of vardenafil were similar to those observed in a control group with normal renal function.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Levitra Professional | 20mg | 360 + 6 Pills | 914.63€ 871.08€ | |
| Levitra Soft Tabs | 20mg | 120 + 8 Pills | 288.52€ 274.78€ | |
| Levitra Professional | 20mg | 120 + 4 Pills | 348.44€ 331.85€ | |
| Levitra Generic | 60mg | 120 + 8 Pills | 372.33€ 354.60€ | |
| Levitra Generic | 40mg | 10 Pills | 41.37€ 39.40€ | |
| Levitra Soft Tabs | 20mg | 60 + 4 Pills | 178.40€ 169.90€ | |
| Levitra Generic | 10mg | 20 Pills | 46.54€ 44.32€ | |
| Levitra Soft Tabs | 20mg | 180 + 10 Pills | 398.14€ 379.18€ | |
| Levitra Generic | 60mg | 30 + 2 Pills | 109.43€ 104.22€ | |
| Levitra Original | 20mg | 14 + 2 Pills | 102.27€ 97.40€ | |
| Levitra Soft Tabs | 20mg | 20 Pills | 74.68€ 71.12€ | |
| Levitra Professional | 20mg | 90 + 2 Pills | 304.49€ 289.99€ |
In the moderate (CLcr = 30-50 ml/min) or severe (CLcr<30 ml/min) renal impairment groups, the AUC of vardenafil was 20–30% higher compared to that observed in a control group with normal renal function (CLcr>80 ml/min).
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In vitro studies have shown that vardenafil is a selective inhibitor of PDE5. The inhibitory effect of vardenafil is more selective on PDE5 than for other known phosphodiesterases (>15-fold relative to PDE6, >130-fold relative to PDE1, >300-fold relative to PDE11, and >1,000-fold relative to PDE2, 3, 4, 7, 8, 9, and 10). The pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range. Vardenafil is eliminated predominantly by hepatic metabolism, mainly by CYP3A4 and to a minor extent, CYP2C isoforms. Concomitant use with potent CYP3A4 inhibitors such as ritonavir, indinavir, ketoconazole, as well as moderate CYP3A inhibitors such as erythromycin results in significant increases of plasma levels of vardenafil (see PRECAUTIONS, WARNINGS and DOSAGE AND ADMINISTRATION).
Clin. Endocrinol. (Oxf)
Mean vardenafil plasma concentrations measured after the administration of a single oral dose of 20 mg to healthy male volunteers are depicted in Figure 1. Figure 1: Plasma Vardenafil Concentration (Mean ± SD) Curve for a Single 20 mg LEVITRA Dose Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%. Maximum observed plasma concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours (median 60 minutes) after oral dosing in the fasted state. Two food-effect levitra generic no prescription studies were conducted which showed that high-fat meals caused a reduction in Cmax by 18%-50%. The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution.
Is Levitra bad for the kidneys?
Vardenafil and its major circulating metabolite, M1, are highly bound to plasma proteins (about 95% for parent drug and M1). This protein binding is reversible and independent of total drug concentrations. Following a single oral dose of 20 mg vardenafil in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing. Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation liquid levitra at the piperazine moiety of vardenafil. Vardenafil pharmacokinetics have not been evaluated in patients requiring renal dialysis (see PRECAUTIONS, Renal Insufficiency, and DOSAGE AND ADMINISTRATION). Hepatic Insufficiency: In volunteers with mild hepatic impairment (Child-Pugh A), the Cmax and AUC following a 10 mg vardenafil dose were increased by 22% and 17%, respectively, compared to healthy control subjects.
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The plasma concentration of M1 is approximately 26% that of the parent compound. This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. Therefore, M1 accounts for approximately 7% of total pharmacologic activity. The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours. After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose). In volunteers with moderate hepatic impairment (Child-Pugh B), the Cmax and AUC following a 10 mg vardenafil dose were increased by 130% and 160%, respectively, compared to healthy control subjects.
- There is no clinical evidence that long-term use leads to tolerance or dependence.
- The medication does not cause addiction in the traditional sense.
- Some patients may develop a psychological reliance on the medication for performance.
- It is not known to cause permanent changes to penile tissue or function.
- Long-term safety data from ongoing studies and post-marketing surveillance is reassuring.
- Regular follow-up with a doctor is recommended for ongoing treatment.
Consequently, a starting dose of 5 mg is recommended for patients with moderate hepatic impairment, and the maximum dose should not exceed 10 mg (see PRECAUTIONS and DOSAGE AND ADMINISTRATION).
¿Cuáles son los posibles efectos secundarios de vardenafil?
It is a prescription medication containing Vardenafil, and U.S. regulations require a licensed healthcare provider to assess suitability, dosage, and safety before use to ensure proper management of Erectile Dysfunction. Yes, 20 mg of Levitra is considered a strong dose. It is usually recommended for individuals who do not respond well to lower strengths. Since it contains Vardenafil, a potent PDE5i, users should follow medical advice to ensure safe and effective results.
What should I do if I miss a dose of vardenafil?
Levitra 20mg typically lasts 4 to 5 hours, with effects peaking around 1 hour after intake and potentially extending up to 8 hours in some individuals. It supports erections during sexual stimulation within this window but requires only one dose per 24 hours. Take one 20mg tablet orally about 25-60 minutes before sexual activity. Swallow whole with water, with or without food, and avoid high-fat meals that may delay the effects. Sexual stimulation is required for it to work.
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Consult a healthcare professional for personalized advice. It is taken only when needed before sexual activity, as using the highest strength every day may increase the risk of side effects. A healthcare professional can recommend a safer daily dose if appropriate. No, Levitra is not inherently bad for the kidneys when used as prescribed. Individuals with severe kidney disease require dose adjustments due to slower medication clearance, increasing side effect risks. Vardenafil has not been evaluated in patients with severe (Child-Pugh C) hepatic impairment.
| Mechanism of Action | Description | Notes |
|---|---|---|
| PDE-5 Enzyme Inhibition | Inhibits phosphodiesterase type 5 enzyme in smooth muscles | Enhances blood flow to the penis |
| cGMP Levels | Increases cyclic guanosine monophosphate (cGMP) levels in corpus cavernosum | Facilitates erection in response to sexual stimuli |
| Effect Duration | About 4-5 hours | Peak plasma concentration reached in about 1 hour |
| Influence on Blood Pressure | May cause slight decrease in blood pressure | Caution in patients on antihypertensives |
In a clinical pharmacology study of patients with erectile dysfunction, single doses of vardenafil 20 mg caused a mean maximum decrease in supine blood pressure of 7 mmHg systolic and 8 mmHg diastolic (compared to placebo), accompanied by a mean maximum increase of heart rate of 4 beats per minute.
| Aspect | Description | Notes |
|---|---|---|
| Active Ingredient | Vardenafil | PDE-5 inhibitor |
| Dosage Forms | Tablets, sublingual | 20mg is standard for adult use |
| Manufacturer | Bayer Pharmaceuticals | Globally recognized brand |
| Approved Uses | Erectile Dysfunction | Prescribed by healthcare providers |
| Common Side Effects | Headache, flushing, nasal congestion | Usually mild and temporary |
| Onset of Action | Approximately 25-60 minutes | Varies by individual |
| Duration of Effect | Up to 4-5 hours | Depends on individual metabolism |
The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing. Following multiple dosing for 31 days, similar blood pressure responses were observed on Day 31 as on Day 1.
- Levitra 20mg users should monitor for vision changes like blurred vision.
- Its absorption rate means it’s best taken about an hour before activity.
- The medication has been proven to improve erectile function in clinical trials.
- Some users may experience chest pain; seek emergency medical help if so.
- Levitra’s approval came after extensive safety and efficacy testing.
Vardenafil may add to the blood pressure lowering effects of antihypertensive agents (see PRECAUTIONS, Drug Interactions). A study was conducted in which the blood pressure and heart rate response to 0.4 mg nitroglycerin (NTG) sublingually was evaluated in 18 healthy subjects following pretreatment with LEVITRA 20 mg at various times before NTG administration. LEVITRA 20 mg caused an additional time-related reduction in blood pressure and increase in heart rate in association with NTG administration.
- The onset of action for the film-coated tablet is typically 25-60 minutes.
- The orally disintegrating tablet may have a slightly faster onset of action.
- Individual response time can vary based on metabolism, food, and other factors.
- The duration of effect is usually sufficient for most sexual activity.
- The window of opportunity is often described as up to 5 hours.
- The medication does not cause an automatic erection; stimulation is required.